Publications

Find our latest publications on PubMed

Selected publications of the last 5 years:

• Letian A, Lemma EY, Cavaliere P, Dephoure N, Altorki NK, McGraw TE. Proximity proteome mapping reveals PD-L1-dependent pathways disrupted by anti-PD-L1 antibody specifically in EGFR-mutant lung cancer cells. Cell Commun Signal. 2023 Mar 13;21(1):58. doi: 10.1186/s12964-023-01084-6. PMID: 36915197; PMCID: PMC10010028. 

• Erik Wennerberg, Sumit Mukherjee, Sheila Spada, Clarey Hung, Christopher J. Agrusa, Chuang Chen, Amanda Valeta-Magara, Nils-Petter Rudqvist, Samantha J. Van Nest, Mohamed K. Kamel, Abu Nasar, Navneet Narula, Vivek Mittal, Geoffrey J. Markowitz, Xi Kathy Zhou, Prasad S. Adusumilli, Alain C. Borczuk, Thomas E. White, Abdul G. Khan, Paul J. Balderes, Ivo C. Lorenz, Nasser Altorki, Sandra Demaria, Timothy E. McGraw, Brendon M. Stiles. Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non–small cell lung cancer. Science Translational Medicine, 2022; 14 (636) DOI: 10.1126/scitranslmed.abe8195

• Picatoste B, Yammine L, Leahey RA, Soares D, Johnson EF, Cohen P, McGraw TE. Defective insulin-stimulated GLUT4 translocation in brown adipocytes induces systemic glucose homeostasis dysregulation independent of thermogenesis in female mice. Mol Metab. 2021 Nov;53:101305. doi: 10.1016/j.molmet.2021.101305. Epub 2021 Jul 21. PMID: 34303022; PMCID: PMC8363886.

• Altorki NK, McGraw TE, Borczuk AC, Saxena A, Port JL, Stiles BM, Lee BE, Sanfilippo NJ, Scheff RJ, Pua BB, Gruden JF, Christos PJ, Spinelli C, Gakuria J, Uppal M, Bhinder B, Elemento O, Ballman KV, Formenti SC. Neoadjuvant durvalumab with or without stereotactic body radiotherapy in patients with early-stage non-small-cell lung cancer: a single-centre, randomised phase 2 trial. Lancet Oncol. 2021;22(6):824-35. Epub 20210518. doi: 10.1016/S1470-2045(21)00149-2. PubMed PMID: 34015311. 

• Santoro A, McGraw TE, Kahn BB. Insulin action in adipocytes, adipose remodeling, and systemic effects. Cell Metab. 2021 Apr 6;33(4):748-757. doi: 10.1016/j.cmet.2021.03.019. PMID: 33826917; PMCID: PMC8078167.

• Brumfield A, Chaudhary N, Molle D, Wen J, Graumann J, McGraw TE. Insulin-promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10. Mol Biol Cell. 2021 Jan 1;32(1):57-73. doi: 10.1091/mbc.E20-06-0356. Epub 2020 Nov 11. PMID: 33175605; PMCID: PMC8098823.

• Yammine L, Picatoste B, Abdullah N, Soares D, Leahey RA, Gómez-Banoy N, Rosselot C, Wen J, Lo JC, Garcia-Ocaña A, McGraw TE. A common human variant of GIPR improves systemic glucose homeostasis in a sexual dimorphic manner. bioRxiv 2020.05.12.091025; doi: https://doi.org/10.1101/2020.05.12.091025 

• Beg M, Abdullah N, Thowfeik FS, Altorki NK, McGraw TE. Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake. Elife. 2017 Jun 7;6:e26896. doi: 10.7554/eLife.26896. PMID: 28589878; PMCID: PMC5462539.

• Chaudhary N, Gonzalez E, Chang SH, Geng F, Rafii S, Altorki NK, McGraw TE. Adenovirus Protein E4-ORF1 Activation of PI3 Kinase Reveals Differential Regulation of Downstream Effector Pathways in Adipocytes. Cell Rep. 2016 Dec 20;17(12):3305-3318. doi: 10.1016/j.celrep.2016.11.082. PMID: 28009298; PMCID: PMC5193245.

• Abdullah N, Beg M, Soares D, Dittman JS, McGraw TE. Downregulation of a GPCR by β-Arrestin2-Mediated Switch from an Endosomal to a TGN Recycling Pathway. Cell Rep. 2016 Dec 13;17(11):2966-2978. doi: 10.1016/j.celrep.2016.11.050. PMID: 27974210; PMCID: PMC5161243.

• Bruno J, Brumfield A, Chaudhary N, Iaea D, McGraw TE. SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes. J Cell Biol. 2016 Jul 4;214(1):61-76. doi: 10.1083/jcb.201509052. Epub 2016 Jun 27. PMID: 27354378; PMCID: PMC4932369.

• Vazirani RP, Verma A, Sadacca LA, Buckman MS, Picatoste B, Beg M, Torsitano C, Bruno JH, Patel RT, Simonyte K, Camporez JP, Moreira G, Falcone DJ, Accili D, Elemento O, Shulman GI, Kahn BB, McGraw TE. Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance. Diabetes. 2016 Jun;65(6):1577-89. doi: 10.2337/db15-1128. Epub 2016 Mar 25. PMID: 27207531; PMCID: PMC4878419.