Publications

Find our latest publications on PubMed

Selected publications of the last 5 years:

• Altorki, N. K., Walsh, Z. H., Melms, J. C., Port, J. L., Lee, B. E., Nasar, A., Spinelli, C., Caprio, L., Rogava, M., Ho, P., Christos, P. J., Saxena, A., Elemento, O., Bhinder, B., Ager, C., Amin, A. D., Sanfilippo, N. J., Mittal, V., Borczuk, A. C., Formenti, S. C., … McGraw, T. E. (2023). Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications, 14(1), 8435. https://doi.org/10.1038/s41467-023-44195-x 

• Ray, A., Wen, J., Yammine, L., Culver, J., Parida, I. S., Garren, J., Xue, L., Hales, K., Xiang, Q., Birnbaum, M. J., Zhang, B. B., Monetti, M., & McGraw, T. E. (2023). Regulated dynamic subcellular GLUT4 localization revealed by proximal proteome mapping in human muscle cells. Journal of cell science, 136(23), jcs261454. https://doi.org/10.1242/jcs.261454 

• Yammine, L., Picatoste, B., Abdullah, N., Leahey, R. A., Johnson, E. F., Gómez-Banoy, N., Rosselot, C., Wen, J., Hossain, T., Goncalves, M. D., Lo, J. C., Garcia-Ocaña, A., & McGraw, T. E. (2023). Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant. Molecular metabolism, 78, 101831. https://doi.org/10.1016/j.molmet.2023.101831 

• Markowitz, G. J., Ban, Y., Tavarez, D. A., Yoffe, L., Podaza, E., He, Y., Martin, M. T., Crowley, M. J. P., Sandoval, T. A., Gao, D., Martin, M. L., Elemento, O., Cubillos-Ruiz, J. R., McGraw, T. E., Altorki, N. K., & Mittal, V. (2023). Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve checkpoint blockade. Research square, rs.3.rs-3356477. https://doi.org/10.21203/rs.3.rs-3356477/v1 

• Lemma, E. Y., Letian, A., Altorki, N. K., & McGraw, T. E. (2023). Regulation of PD-L1 Trafficking from Synthesis to Degradation. Cancer immunology research, 11(7), 866–874. https://doi.org/10.1158/2326-6066.CIR-22-0953 

• Letian A, Lemma EY, Cavaliere P, Dephoure N, Altorki NK, McGraw TE. Proximity proteome mapping reveals PD-L1-dependent pathways disrupted by anti-PD-L1 antibody specifically in EGFR-mutant lung cancer cells. Cell Commun Signal. 2023 Mar 13;21(1):58. doi: 10.1186/s12964-023-01084-6. PMID: 36915197; PMCID: PMC10010028. 

• Erik Wennerberg, Sumit Mukherjee, Sheila Spada, Clarey Hung, Christopher J. Agrusa, Chuang Chen, Amanda Valeta-Magara, Nils-Petter Rudqvist, Samantha J. Van Nest, Mohamed K. Kamel, Abu Nasar, Navneet Narula, Vivek Mittal, Geoffrey J. Markowitz, Xi Kathy Zhou, Prasad S. Adusumilli, Alain C. Borczuk, Thomas E. White, Abdul G. Khan, Paul J. Balderes, Ivo C. Lorenz, Nasser Altorki, Sandra Demaria, Timothy E. McGraw, Brendon M. Stiles. Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non–small cell lung cancer. Science Translational Medicine, 2022; 14 (636) DOI: 10.1126/scitranslmed.abe8195

• Picatoste B, Yammine L, Leahey RA, Soares D, Johnson EF, Cohen P, McGraw TE. Defective insulin-stimulated GLUT4 translocation in brown adipocytes induces systemic glucose homeostasis dysregulation independent of thermogenesis in female mice. Mol Metab. 2021 Nov;53:101305. doi: 10.1016/j.molmet.2021.101305. Epub 2021 Jul 21. PMID: 34303022; PMCID: PMC8363886.

• Altorki NK, McGraw TE, Borczuk AC, Saxena A, Port JL, Stiles BM, Lee BE, Sanfilippo NJ, Scheff RJ, Pua BB, Gruden JF, Christos PJ, Spinelli C, Gakuria J, Uppal M, Bhinder B, Elemento O, Ballman KV, Formenti SC. Neoadjuvant durvalumab with or without stereotactic body radiotherapy in patients with early-stage non-small-cell lung cancer: a single-centre, randomised phase 2 trial. Lancet Oncol. 2021;22(6):824-35. Epub 20210518. doi: 10.1016/S1470-2045(21)00149-2. PubMed PMID: 34015311. 

• Santoro A, McGraw TE, Kahn BB. Insulin action in adipocytes, adipose remodeling, and systemic effects. Cell Metab. 2021 Apr 6;33(4):748-757. doi: 10.1016/j.cmet.2021.03.019. PMID: 33826917; PMCID: PMC8078167.

• Brumfield A, Chaudhary N, Molle D, Wen J, Graumann J, McGraw TE. Insulin-promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10. Mol Biol Cell. 2021 Jan 1;32(1):57-73. doi: 10.1091/mbc.E20-06-0356. Epub 2020 Nov 11. PMID: 33175605; PMCID: PMC8098823.