Welcome to the McGraw Lab in the Biochemistry Department at Weill Cornell Medicine in New York City!
The McGraw laboratory focuses on the mechanisms of receptor trafficking. We study their role on metabolism and on cancer biology. We investigate the Glut4 pathway and its partners during Insulin stimulation, as well as the GIP receptor trafficking and how they impact type 2 diabetes. We also study PD-L1 biology, its trafficking and its role on tumor progression.
To this end, we use quantitative optical microscopy, multiple cell models (muscle, adipocyte, beta-cells, cancer cells), and mouse models to unravel the mechanisms behind our receptors trafficking and their overall impact on whole body systems.